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<?xml version="1.0" encoding="UTF-8"?>
<channelml xmlns="http://morphml.org/channelml/schema"
       xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
       xmlns:meta="http://morphml.org/metadata/schema"
       xsi:schemaLocation="http://morphml.org/channelml/schema  http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd"
       units="Physiological Units"
>


    
<meta:notes>ChannelML file containing a single Channel description from Solinas et al 2007</meta:notes>

    
<channel_type name="KAHP_CML">

        
<status value = "stable">
            
<meta:comment>Note: only mapping available is to NEURON mod file.</meta:comment>
            
<meta:contributor>
                
<meta:name>Padraig Gleeson</meta:name>
            
</meta:contributor>
        
</status>

        
<meta:notes>SK type Ca2+ dependent K+ channel (After HyperPolarizing), based on mod file supplied with Solinas et al 2007 (ModelDB 112685)</meta:notes>


        
<meta:authorList>
            
<meta:modelAuthor>
                
<meta:name>Sergio Solinas</meta:name>
                
<meta:comment>Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998
Last revised: May 2007
</meta:comment>
            
</meta:modelAuthor>

            
<meta:modelAuthor>
                
<meta:name>Lia Forti</meta:name>
                
<meta:comment>Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998
Last revised: May 2007
</meta:comment>
            
</meta:modelAuthor>

            
<meta:modelAuthor>
                
<meta:name>Egidio D'Angelo</meta:name>
                
<meta:comment>Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998
Last revised: May 2007
</meta:comment>
            
</meta:modelAuthor>

            
<meta:modelTranslator>
                
<meta:name>Padraig Gleeson</meta:name>
                
<meta:institution>UCL</meta:institution>
                
<meta:email>p.gleeson - at - ucl.ac.uk</meta:email>
            
</meta:modelTranslator>

            
<meta:modelTranslator>
                
<meta:name>Matteo Farinella</meta:name>
                
<meta:institution>UCL</meta:institution>
                
<meta:email>m.farinella - at - ucl.ac.uk</meta:email>
            
</meta:modelTranslator>
            
        
</meta:authorList>

        
<meta:publication>
            
<meta:fullTitle>Solinas S, Forti L, Cesana E, Mapelli J, De Schutter E, D'Angelo E. (2007) Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells.  Front Cell Neurosci. 2007;1:2.</meta:fullTitle>
            
<meta:pubmedRef>http://www.ncbi.nlm.nih.gov/pubmed/18946520</meta:pubmedRef>
        
</meta:publication>

        
<meta:neuronDBref>
            
<meta:modelName>K channels</meta:modelName>
            
<meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table3</meta:uri>
        
</meta:neuronDBref>

        
<meta:modelDBref>
            
<meta:modelName>Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)</meta:modelName>
            
<meta:uri>http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=112685</meta:uri>
        
</meta:modelDBref>

        
<parameters>
            
<parameter name="invc1" value="80e-3"/>
            
<parameter name="invc2" value="80e-3"/>
            
<parameter name="invc3" value="200e-3"/>

            
<parameter name="invo1" value="1"/>
            
<parameter name="invo2" value="100e-3"/>
            
<parameter name="diro1" value="160e-3"/>
            
<parameter name="diro2" value="1.2"/>

            
<parameter name="dirc2" value="200"/>
            
<parameter name="dirc3" value="160"/>
            
<parameter name="dirc4" value="80"/>

            
<parameter name="diff" value="3"/> <!-- diffusion factor -->

        
</parameters>

        
<current_voltage_relation cond_law="ohmic" ion="k" default_gmax="36" default_erev="-77.0">

            
<conc_dependence name="Calcium" ion="ca" charge="2" variable_name="ca_conc" min_conc="0" max_conc="0.050"/>

            
<q10_settings q10_factor="3" experimental_temp="23"/>

            
<gate name="n" instances="1">
                
                
<closed_state id="c1"/>
                
<closed_state id="c2"/>
                
<closed_state id="c3"/>
                
<closed_state id="c4"/>

                
<open_state id="o1"/>
                
<open_state id="o2"/>
                    
                
<transition name="alpha_c1_c2" from="c1" to="c2" expr_form="generic" expr="dirc2 * (ca_conc*1e6/diff)"/>
                
<transition name="beta_c2_c1" from="c2" to="c1" expr_form="generic" expr="invc1"/>

                
<transition name="alpha_c2_c3" from="c2" to="c3" expr_form="generic" expr="dirc3 * (ca_conc*1e6/diff)"/>
                
<transition name="beta_c3_c2" from="c3" to="c2" expr_form="generic" expr="invc2"/>

                
<transition name="alpha_c3_c4" from="c3" to="c4" expr_form="generic" expr="dirc4 * (ca_conc*1e6/diff)"/>
                
<transition name="beta_c4_c3" from="c4" to="c3" expr_form="generic" expr="invc3"/>

                
<transition name="alpha_c3_o1" from="c3" to="o1" expr_form="generic" expr="diro1"/>
                
<transition name="beta_o1_c3" from="o1" to="c3" expr_form="generic" expr="invo1"/>

                
<transition name="alpha_c4_o2" from="c4" to="o2" expr_form="generic" expr="diro2"/>
                
<transition name="beta_o2_c4" from="o2" to="c4" expr_form="generic" expr="invo2"/>
                    
            
</gate>
        
</current_voltage_relation>
        
    
</channel_type>
        
    
</channelml>