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<?xml version="1.0" encoding="UTF-8"?>

<channelml xmlns="http://morphml.org/channelml/schema"
    xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
    xmlns:meta="http://morphml.org/metadata/schema"
    xsi:schemaLocation="http://morphml.org/channelml/schema  http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd"
    units="SI Units"
>


    
<meta:notes>A channel from Maex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a
    Detailed Network Model of the Cerebellar Granule Cell Layer
</meta:notes>
    
    
<channel_type name="Gran_NaF_98">
              
        
<status value="stable">
            
<meta:comment>Verified equivalence of NEURON and GENESIS mapping to orig GENESIS impl from www.tnb.ua.ac.be</meta:comment>
            
<meta:comment>Updated to post v1.7.3 new ChannelML format</meta:comment>
            
<meta:issue>Quite a small dt (~0.001 ms) is needed to give matching NEURON/GENESIS results for a compartment with just
                this channel (and a leak current)
</meta:issue>
            
<meta:contributor>
                
<meta:name>Padraig Gleeson</meta:name>
            
</meta:contributor>
        
</status>
    
        
<meta:notes>Fast inactivating Na+ channel</meta:notes>
        
        
<meta:authorList>
            
<meta:modelAuthor>
                
<meta:name>Maex, R.</meta:name>
            
</meta:modelAuthor>
            
<meta:modelAuthor>
                
<meta:name>De Schutter, E.</meta:name>
            
</meta:modelAuthor>
            
<meta:modelTranslator>
                
<meta:name>Padraig Gleeson</meta:name>
                
<meta:institution>UCL</meta:institution>    
                
<meta:email>p.gleeson - at - ucl.ac.uk</meta:email>
            
</meta:modelTranslator>
        
</meta:authorList>
        
        
        
<meta:publication>
          
<meta:fullTitle>Maex, R and De Schutter, E.
           Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the
           cerebellar Granule Cell Layer. J Neurophysiol, Nov 1998; 80: 2521 - 2537
</meta:fullTitle>
          
<meta:pubmedRef>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9819260&amp;dopt=Abstract</meta:pubmedRef>
        
</meta:publication>


        
<meta:neuronDBref>
            
<meta:modelName>Na channels</meta:modelName>
            
<meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table2</meta:uri>
        
</meta:neuronDBref>
        
        
<current_voltage_relation cond_law="ohmic" ion="na" default_gmax="546.301" default_erev="0.055">
            
            
<q10_settings q10_factor="3" experimental_temp="17.350264793"/>
            
<offset value="0.010"/>
            
            
<gate name="m" instances="3">
                
<closed_state id="m0"/>
                
<open_state id="m"/>
                    
                
<transition name="alpha" from="m0" to="m" expr_form="exponential" rate="1500" scale="0.012345679" midpoint="-0.039" />
                    
                
<transition name="beta" from="m" to="m0" expr_form="exponential" rate="1500" scale="-0.0151515" midpoint="-0.039" />
                    
                
<time_course name="tau" from="m0" to="m" expr_form="generic" expr="1/(alpha + beta) &lt; 0.00005 ? 0.00005 : 1/(alpha + beta)" />
                    
            
</gate>
        
            
<gate name="h" instances="1">
                
<closed_state id="h0"/>
                
<open_state id="h"/>
                    
                
<transition name="alpha" from="h0" to="h" expr_form="exponential" rate="120" scale="-0.01123596" midpoint="-0.05" />
                    
                
<transition name="beta" from="h" to="h0" expr_form="exponential" rate="120" scale="0.01123596" midpoint="-0.05" />
                    
                
<time_course name="tau" from="h0" to="h" expr_form="generic" expr="1/(alpha + beta) &lt; 0.000225 ? 0.000225 : 1/(alpha + beta)" />
                    
            
</gate>
        
</current_voltage_relation>
        

        
        
<!-- Adding extra table divs due to discontinuity in tau-->
        
<impl_prefs>
            
<table_settings max_v="0.1" min_v="-0.1" table_divisions="4000"/>
        
</impl_prefs>
        
    
</channel_type>
</channelml>