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<?xml version="1.0" encoding="UTF-8"?>
<channelml xmlns="http://morphml.org/channelml/schema"
           xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
           xmlns:meta="http://morphml.org/metadata/schema"
           xsi:schemaLocation="http://morphml.org/channelml/schema  http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd"
           units="Physiological Units"
>


    
<meta:notes>ChannelML file based on Traub et al. 2003</meta:notes>

    
<channel_type name="kc_fast" density="yes">
        
        
<status value="stable">
            
<meta:comment>Verified equivalence of NEURON and GENESIS mapping to orig NEURON mod impl at 0.02ms dt with current pulse</meta:comment>
            
<meta:issue>In original mod, m is initialised to 0, as opposed to minf at t=0. ChannelML impl corrects this</meta:issue>
            
<meta:contributor>
                
<meta:name>Padraig Gleeson</meta:name>
            
</meta:contributor>
            
<meta:contributor>
                
<meta:name>Yoana Dimitrova</meta:name>
            
</meta:contributor>
        
</status>
        
        
<meta:notes>Fast voltage and [Ca2+] dependent K conductance (BK channel). Based on NEURON port of FRB L2/3 model from Traub et al 2003. Same channel used in Traub et al 2005</meta:notes>
        
        
<meta:authorList>
            
<meta:modelAuthor>
                
<meta:name>Roger D Traub</meta:name>
                
<meta:comment>Conversion of FORTRAN model to NEURON. See Traub et al 2003 for detailed origin of channels</meta:comment>
            
</meta:modelAuthor>
            
<meta:modelAuthor>
                
<meta:name>Maciej Lazarewicz</meta:name>
                
<meta:comment>Conversion of FORTRAN model to NEURON. See Traub et al 2003 for detailed origin of channels</meta:comment>
            
</meta:modelAuthor>
            
<meta:modelTranslator>
                
<meta:name>Padraig Gleeson</meta:name>
                
<meta:institution>UCL</meta:institution>
                
<meta:email>p.gleeson - at - ucl.ac.uk</meta:email>
            
</meta:modelTranslator>
            
<meta:modelTranslator>
                
<meta:name>Yoana Dimitrova</meta:name>
                
<meta:institution>UCL</meta:institution>
            
</meta:modelTranslator>
        
</meta:authorList>

        
<meta:publication>
            
<meta:fullTitle>Roger D. Traub, Eberhard H. Buhl, Tengis Gloveli, and Miles A. Whittington                
Fast Rhythmic Bursting Can Be Induced in Layer 2/3 Cortical Neurons by Enhancing Persistent Na+ Conductance or by Blocking BK Channels
J Neurophysiol 89: 909-921, 2003
</meta:fullTitle>
            
<meta:pubmedRef>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=12574468</meta:pubmedRef>
        
</meta:publication>

        
<meta:publication>
            
<meta:fullTitle>Roger D. Traub, Diego Contreras, Mark O. Cunningham, Hilary Murray, Fiona E. N. LeBeau, Anita Roopun, Andrea Bibbig, W. Bryan Wilent, Michael J. Higley, and Miles A. Whittington
Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts.
J. Neurophysiol. 93, 2194-2232, 2005
</meta:fullTitle>
            
<meta:pubmedRef>http://www.ncbi.nlm.nih.gov/pubmed/15525801?dopt=Abstract</meta:pubmedRef>
        
</meta:publication>
        
        
<meta:neuronDBref>
            
<meta:modelName>K channels</meta:modelName>
            
<meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table3</meta:uri>
        
</meta:neuronDBref>
        
        
<meta:modelDBref>
            
<meta:modelName>Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)</meta:modelName>
            
<meta:uri>http://senselab.med.yale.edu/ModelDB/ShowModel.asp?model=20756</meta:uri>
        
</meta:modelDBref>

        
<meta:modelDBref>
            
<meta:modelName>A single column thalamocortical network model (Traub et al 2005)</meta:modelName>
            
<meta:uri>http://senselab.med.yale.edu/ModelDb/ShowModel.asp?model=45539</meta:uri>
        
</meta:modelDBref>

        
<parameters>
            
<parameter name="speedup_factor" value ="2"/>  
        
</parameters>
    
        
<current_voltage_relation cond_law="ohmic" ion="k" default_gmax="12" default_erev="-95">
            
            
<!-- New element in v1.7.1, used for time independent concentration factor -->
            
<conc_factor  ion="ca" charge="2" variable_name="ca_conc" expr="ca_conc &lt; 0.00025 ? (ca_conc / 0.00025) : 1" min_conc="0" max_conc="0.001"/>

            
<gate name="m" instances="1">
                
                
<closed_state id="m0"/>
                
<open_state id="m"/>
                    
                
<transition name="alpha" from="m0" to="m" expr_form="generic" expr="v &lt; -10 ? speedup_factor * (2 / 37.95) * ( exp ( ((v + 50 ) / 11) - (( v + 53.5) / 27) ) ) : speedup_factor * 2 * (exp ( ( (-1 * v) - 53.5 ) / 27 ))" />
                    
                
<transition name="beta" from="m" to="m0" expr_form="generic" expr="v &lt; -10 ? speedup_factor * 2 * (exp ( ( (-1 * v) - 53.5 ) / 27 )) - alpha : speedup_factor * 0.0" />
                    
            
</gate>
            
        
</current_voltage_relation>
            
        
<impl_prefs>
            
<comment>This will ensure more points in calcium dependence table</comment>
            
<table_settings max_v="140" min_v="-120" table_divisions="1041"/>
        
</impl_prefs>
        
    
</channel_type>
</channelml>