Transforming XML file: NeuroMLFiles/Examples/ChannelMLSyns/NMDA.xml using XSL file: NeuroMLFiles/Schemata/v1.8.1/Level3/NeuroML_Level3_v1.8.1_HTML.xsl

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Converting the file: NMDA.xml

General notes
Notes present in ChannelML file
ChannelML file describing a synaptic mechanism

Unit system of ChannelML file
This can be either SI Units or Physiological Units (milliseconds, centimeters, millivolts, etc.)
SI Units

Synapse: NMDA

Status of element in file
As described in ChannelML file
Example of an NMDA receptor synaptic mechanism, based on Maex DeSchutter 1998, Gabbiani et al, 1994. Mappings exist for NEURON and GENESIS.
Translators of the model to NeuroML:
   Padraig Gleeson  (UCL)  p.gleeson - at -
Referenced publicationGabbiani F, Midtgaard J, Knopfel T. Synaptic integration in a model of cerebellar granule cells. Pubmed
Referenced publicationMaex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the cerebellar Granule Cell Layer. J Neurophysiol, Nov 1998; 80: 2521 - 2537 Pubmed
Reference in NeuronDB Glutamate receptors, Ionotropic

Synaptic Mechanism Model: Blocking Synapse

The model underlying the synaptic mechanism

Maximum conductance
The peak conductance which the synapse will reach
2e-8 S
Rise time
Characteristic time (tau) over which the double exponential synaptic conductance rises
1e-3 s
Decay time
Characteristic time (tau) over which the double exponential synaptic conductance decays
13.3333e-3 s
Reversal potential
The effective reversal potential for the ion flow through the synapse when the conductance is non zero
0 V

Block of synaptic mechanism

Information on how a species modifies the conductance of the synapse

Ion or molecule which blocks the channel
Concentration of species
1.2 mole m-3 (or mM)
eta0.5206857564 mole-1 m3 (or mM-1)
gamma62 V-1
Expression defining block
Gblock(v) = 1
1+ eta * [mg] * e(-1 * gamma * v)

Time to transform file: 0.121 secs