Name  KAHP_CML 
Status 
Status of element in file 
 Stable
Comment: Note: only mapping available is to NEURON mod file. Contributor: Padraig Gleeson 
Description 
As described in the ChannelML file 
 SK type Ca2+ dependent K+ channel (After HyperPolarizing), based on mod file supplied with Solinas et al 2007 (ModelDB 112685) 
Authors 
Authors of original model: 
Sergio Solinas
(Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998
Last revised: May 2007)

Lia Forti
(Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998
Last revised: May 2007)

Egidio D'Angelo
(Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998
Last revised: May 2007)

Translators of the model to NeuroML: 
Padraig Gleeson
(UCL)
p.gleeson  at  ucl.ac.uk 
Matteo Farinella
(UCL)
m.farinella  at  ucl.ac.uk 

Referenced publication  Solinas S, Forti L, Cesana E, Mapelli J, De Schutter E, D'Angelo E. (2007) Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. Front Cell Neurosci. 2007;1:2.
Pubmed

Reference in NeuronDB 
K channels

Reference in ModelDB 
Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)

Current voltage relationship  ohmic 
Ion involved in channel 
The ion which is actually flowing through the channel and its default reversal potential.
Note that the reversal potential will normally depend on the internal and external concentrations of the ion at the segment on which the channel is placed. 
 k (default E_{k} = 77.0 mV)

Default maximum conductance density 
Note that the conductance density of the channel will be set when it is placed on the cell. 
 G_{max} = 36 mS cm^{2} 
Conductance expression 
Expression giving the actual conductance as a function of time and voltage 
 G_{k}(v,t) = G_{max}
* n(v,t)

Current due to channel 
Ionic current through the channel 
 I_{k}(v,t) =
G_{k}(v,t) * (v  E_{k}) 
Q10 scaling 
Q10 scaling affects the tau in the rate equations. It allows rate equations experimentally calculated at one temperature
to be used at a different temperature. 

Q10 adjustment applied to gates:  all 
Q10_factor:  3 
Experimental temperature (at which rate constants below were determined):  23 ^{o}C 
Expression for tau at T using tauExp as calculated from rate equations: 
tau(T) = tauExp / 3^((T  23)/10) 

Concentration dependence of gates 
The dynamics of one or more gates are dependent on both the potential difference across the
channel, and on the concentration of the substance specified here 
 Name: Calcium
Ion: ca, charge: 2
Variable as used in rate equations: ca_conc
Min concentration: 0 (required by simulators for table of voltage/conc dependencies)
Max concentration: 0.050 (required by simulators for table of voltage/conc dependencies)

Parameters 
A number of parameters which can be used in the rate expressions, etc. for the channels.
These should be publicly accessible in the objects implementing the channel. 

invc1 = 80e3
invc2 = 80e3
invc3 = 200e3
invo1 = 1
invo2 = 100e3
diro1 = 160e3
diro2 = 1.2
dirc2 = 200
dirc3 = 160
dirc4 = 80
diff = 3
