Transforming XML file: NeuroMLFiles/Examples/ChannelML/SK_KineticScheme.xml using XSL file: NeuroMLFiles/Schemata/v1.8.1/Level3/NeuroML_Level3_v1.8.1_HTML.xsl

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Converting the file: SK_KineticScheme.xml

General notes
Notes present in ChannelML file
ChannelML file containing a single Channel description from Solinas et al 2007

Unit system of ChannelML file
This can be either SI Units or Physiological Units (milliseconds, centimeters, millivolts, etc.)
Physiological Units

Channel: KAHP_CML

NameKAHP_CML
Status
Status of element in file
Stable
Comment: Note: only mapping available is to NEURON mod file.
Contributor: Padraig Gleeson
Description
As described in the ChannelML file
SK type Ca2+ dependent K+ channel (After HyperPolarizing), based on mod file supplied with Solinas et al 2007 (ModelDB 112685)
Authors
Authors of original model:
   Sergio Solinas   (Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998 Last revised: May 2007)
   Lia Forti   (Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998 Last revised: May 2007)
   Egidio D'Angelo   (Cited implementer according to the original .mod file. Note from original mod file: Based on data from: Hirschberg, Maylie, Adelman, Marrion J Gen Physiol 1998 Last revised: May 2007)
Translators of the model to NeuroML:
   Padraig Gleeson  (UCL)  p.gleeson - at - ucl.ac.uk
   Matteo Farinella  (UCL)  m.farinella - at - ucl.ac.uk
Referenced publicationSolinas S, Forti L, Cesana E, Mapelli J, De Schutter E, D'Angelo E. (2007) Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. Front Cell Neurosci. 2007;1:2. Pubmed
Reference in NeuronDB K channels
Reference in ModelDB Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)
Current voltage relationshipohmic
Ion involved in channel
The ion which is actually flowing through the channel and its default reversal potential. Note that the reversal potential will normally depend on the internal and external concentrations of the ion at the segment on which the channel is placed.
k (default Ek = -77.0 mV)
Default maximum conductance density
Note that the conductance density of the channel will be set when it is placed on the cell.
Gmax = 36 mS cm-2
Conductance expression
Expression giving the actual conductance as a function of time and voltage
Gk(v,t) = Gmax * n(v,t)
Current due to channel
Ionic current through the channel
Ik(v,t) = Gk(v,t) * (v - Ek)
Q10 scaling
Q10 scaling affects the tau in the rate equations. It allows rate equations experimentally calculated at one temperature to be used at a different temperature.
Q10 adjustment applied to gates:    all
Q10_factor:    3
Experimental temperature (at which rate constants below were determined):    23 oC
Expression for tau at T using tauExp as calculated from rate equations:    tau(T) = tauExp / 3^((T - 23)/10)
Concentration dependence of gates
The dynamics of one or more gates are dependent on both the potential difference across the channel, and on the concentration of the substance specified here
Name: Calcium
Ion: ca, charge: 2
Variable as used in rate equations: ca_conc
Min concentration: 0 (required by simulators for table of voltage/conc dependencies)
Max concentration: 0.050 (required by simulators for table of voltage/conc dependencies)
Parameters
A number of parameters which can be used in the rate expressions, etc. for the channels. These should be publicly accessible in the objects implementing the channel.
invc1 = 80e-3
invc2 = 80e-3
invc3 = 200e-3
invo1 = 1
invo2 = 100e-3
diro1 = 160e-3
diro2 = 1.2
dirc2 = 200
dirc3 = 160
dirc4 = 80
diff = 3


Gate: n

The equations below determine the dynamics of gating state n

Instances of gating elements1
Closed statec1
Closed statec2
Closed statec3
Closed statec4
Open stateo1
Open stateo2
 
    Transition: alpha_c1_c2 from c1 to c2
Generic expressionalpha_c1_c2(v) = dirc2 * (ca_conc*1e6/diff)
 
    Transition: beta_c2_c1 from c2 to c1
Generic expressionbeta_c2_c1(v) = invc1
 
    Transition: alpha_c2_c3 from c2 to c3
Generic expressionalpha_c2_c3(v) = dirc3 * (ca_conc*1e6/diff)
 
    Transition: beta_c3_c2 from c3 to c2
Generic expressionbeta_c3_c2(v) = invc2
 
    Transition: alpha_c3_c4 from c3 to c4
Generic expressionalpha_c3_c4(v) = dirc4 * (ca_conc*1e6/diff)
 
    Transition: beta_c4_c3 from c4 to c3
Generic expressionbeta_c4_c3(v) = invc3
 
    Transition: alpha_c3_o1 from c3 to o1
Generic expressionalpha_c3_o1(v) = diro1
 
    Transition: beta_o1_c3 from o1 to c3
Generic expressionbeta_o1_c3(v) = invo1
 
    Transition: alpha_c4_o2 from c4 to o2
Generic expressionalpha_c4_o2(v) = diro2
 
    Transition: beta_o2_c4 from o2 to c4
Generic expressionbeta_o2_c4(v) = invo2



Time to transform file: 0.115 secs