Transforming XML file: NeuroMLFiles/Examples/ChannelML/KChan_KineticScheme.xml using XSL file: NeuroMLFiles/Schemata/v1.8.1/Level3/NeuroML_Level3_v1.8.1_HTML.xsl

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Converting the file: KChan_KineticScheme.xml

General notes
Notes present in ChannelML file
Example of 5 state kinetic scheme K conductance specified in ChannelML.

Unit system of ChannelML file
This can be either SI Units or Physiological Units (milliseconds, centimeters, millivolts, etc.)
Physiological Units

Channel: KChannelKS

NameKChannelKS
Description
As described in the ChannelML file
K conductance with 5 kinetic states. NOTE: currently a mapping is only provided to the NEURON Channel Builder format and PSICS
Current voltage relationshipohmic
Ion involved in channel
The ion which is actually flowing through the channel and its default reversal potential. Note that the reversal potential will normally depend on the internal and external concentrations of the ion at the segment on which the channel is placed.
k (default Ek = -77.0 mV)
Default maximum conductance density
Note that the conductance density of the channel will be set when it is placed on the cell.
Gmax = 36 mS cm-2
Conductance expression
Expression giving the actual conductance as a function of time and voltage
Gk(v,t) = Gmax * n(v,t)
Current due to channel
Ionic current through the channel
Ik(v,t) = Gk(v,t) * (v - Ek)


Gate: n

The equations below determine the dynamics of gating state n

Instances of gating elements1
Closed staten0
Closed staten1
Closed staten2
Closed staten3
Open staten   (fractional conductance: 1)
 
    Transition: alpha_n0_n1 from n0 to n1
Expressionalpha_n0_n1(v) = A*((v-V1/2)/B) / (1 - exp(-(v-V1/2)/B))    (exp_linear)
Parameter values A = 0.4 ms-1   B = 10 mV   V1/2 = -55 mV
Substituted
alpha_n0_n1(v) = 0.4 * ( v - (-55)) / 10
1- e -(( v - (-55)) / 10)
 
    Transition: beta_n0_n1 from n1 to n0
Expressionbeta_n0_n1(v) = A*exp((v-V1/2)/B)    (exponential)
Parameter values A = 0.125 ms-1   B = -80 mV   V1/2 = -65 mV
Substituted beta_n0_n1(v) = 0.125 * e (v - (-65))/-80
 
    Transition: alpha_n1_n2 from n1 to n2
Expressionalpha_n1_n2(v) = A*((v-V1/2)/B) / (1 - exp(-(v-V1/2)/B))    (exp_linear)
Parameter values A = 0.3 ms-1   B = 10 mV   V1/2 = -55 mV
Substituted
alpha_n1_n2(v) = 0.3 * ( v - (-55)) / 10
1- e -(( v - (-55)) / 10)
 
    Transition: beta_n1_n2 from n2 to n1
Expressionbeta_n1_n2(v) = A*exp((v-V1/2)/B)    (exponential)
Parameter values A = 0.25 ms-1   B = -80 mV   V1/2 = -65 mV
Substituted beta_n1_n2(v) = 0.25 * e (v - (-65))/-80
 
    Transition: alpha_n2_n3 from n2 to n3
Expressionalpha_n2_n3(v) = A*((v-V1/2)/B) / (1 - exp(-(v-V1/2)/B))    (exp_linear)
Parameter values A = 0.2 ms-1   B = 10 mV   V1/2 = -55 mV
Substituted
alpha_n2_n3(v) = 0.2 * ( v - (-55)) / 10
1- e -(( v - (-55)) / 10)
 
    Transition: beta_n2_n3 from n3 to n2
Expressionbeta_n2_n3(v) = A*exp((v-V1/2)/B)    (exponential)
Parameter values A = 0.375 ms-1   B = -80 mV   V1/2 = -65 mV
Substituted beta_n2_n3(v) = 0.375 * e (v - (-65))/-80
 
    Transition: alpha_n3_n from n3 to n
Expressionalpha_n3_n(v) = A*((v-V1/2)/B) / (1 - exp(-(v-V1/2)/B))    (exp_linear)
Parameter values A = 0.1 ms-1   B = 10 mV   V1/2 = -55 mV
Substituted
alpha_n3_n(v) = 0.1 * ( v - (-55)) / 10
1- e -(( v - (-55)) / 10)
 
    Transition: beta_n3_n from n to n3
Expressionbeta_n3_n(v) = A*exp((v-V1/2)/B)    (exponential)
Parameter values A = 0.5 ms-1   B = -80 mV   V1/2 = -65 mV
Substituted beta_n3_n(v) = 0.5 * e (v - (-65))/-80



Time to transform file: 0.119 secs