Transforming XML file: NeuroMLFiles/Examples/ChannelML/KCa_Channel.xml using XSL file: NeuroMLFiles/Schemata/v1.8.1/Level3/NeuroML_Level3_v1.8.1_HTML.xsl

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Converting the file: KCa_Channel.xml

General notes
Notes present in ChannelML file
A channel from Maex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the Cerebellar Granule Cell Layer

Unit system of ChannelML file
This can be either SI Units or Physiological Units (milliseconds, centimeters, millivolts, etc.)
SI Units

Channel: Gran_KCa_98

Status of element in file
Issue: This ChannelML file is intended ONLY to replicate the original GENESIS functionality. A new Granule cell model is being developed based on D'Angelo et al 2001 and Berends, Maex and De Schutter 2005, and the ChannelML files will be updated
Contributor: Padraig Gleeson
As described in the ChannelML file
Calcium concentration dependent K+ channel
Authors of original model:
   Maex, R.
   De Schutter, E.
Translators of the model to NeuroML:
   Padraig Gleeson  (UCL)  p.gleeson - at -
Referenced publicationMaex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the cerebellar Granule Cell Layer. J Neurophysiol, Nov 1998; 80: 2521 - 2537 Pubmed
Reference in NeuronDB K+ channels
Current voltage relationshipohmic
Ion involved in channel
The ion which is actually flowing through the channel and its default reversal potential. Note that the reversal potential will normally depend on the internal and external concentrations of the ion at the segment on which the channel is placed.
k (default Ek = -0.09 V)
Default maximum conductance density
Note that the conductance density of the channel will be set when it is placed on the cell.
Gmax = 0.179811 S m-2
Conductance expression
Expression giving the actual conductance as a function of time and voltage
Gk(v,t) = Gmax * m(v,t)
Current due to channel
Ionic current through the channel
Ik(v,t) = Gk(v,t) * (v - Ek)
Q10 scaling
Q10 scaling affects the tau in the rate equations. It allows rate equations experimentally calculated at one temperature to be used at a different temperature.
Q10 adjustment applied to gates:    all
Q10_factor:    3
Experimental temperature (at which rate constants below were determined):    17.350264793 oC
Expression for tau at T using tauExp as calculated from rate equations:    tau(T) = tauExp / 3^((T - 17.350264793)/10)
Voltage offset
This introduces a shift in the voltage dependence of the rate equations. If, for example, the equation parameters being used in a model were from a different species, this offset can be introduced to alter the firing threshold to something closer to the species being modelled. See mappings for details.
0.010 V
Concentration dependence of gates
The dynamics of one or more gates are dependent on both the potential difference across the channel, and on the concentration of the substance specified here
Name: Calcium
Ion: ca, charge: 2
Variable as used in rate equations: ca_conc
Min concentration: 7.55e-7 (required by simulators for table of voltage/conc dependencies)
Max concentration: 0.050 (required by simulators for table of voltage/conc dependencies)

Gate: m

The equations below determine the dynamics of gating state m

Instances of gating elements1
Closed statem0
Open statem
    Transition: alpha from m0 to m
Generic expressionalpha(v) = 2500/(1 + ( (1.5e-3 *(exp (-85*v))) / ca_conc))
    Transition: beta from m to m0
Generic expressionbeta(v) = 1500/(1 + (ca_conc / (1.5e-4 * (exp (-77*v)))))

Time to transform file: 0.121 secs