<?xml version="1.0" encoding="UTF-8"?>

<channelml xmlns="http://morphml.org/channelml/schema"
    xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
    xmlns:meta="http://morphml.org/metadata/schema"
    xsi:schemaLocation="http://morphml.org/channelml/schema  http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd"
    units="SI Units">

    <meta:notes>A channel from Maex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a
    Detailed Network Model of the Cerebellar Granule Cell Layer</meta:notes>
    
    <channel_type name="Gran_KCa_98">
        
        <status value="stable">
            <meta:issue>This ChannelML file is intended ONLY to replicate the original GENESIS functionality. A new Granule cell model is being developed based on
                D'Angelo et al 2001 and Berends, Maex and De Schutter 2005, and the ChannelML files will be updated</meta:issue>
            <meta:contributor>
                <meta:name>Padraig Gleeson</meta:name>
            </meta:contributor>
        </status>
    
        <meta:notes>Calcium concentration dependent K+ channel</meta:notes>
    
        <meta:authorList>
            <meta:modelAuthor>
                <meta:name>Maex, R.</meta:name>
            </meta:modelAuthor>
            <meta:modelAuthor>
                <meta:name>De Schutter, E.</meta:name>
            </meta:modelAuthor>
            <meta:modelTranslator>
                <meta:name>Padraig Gleeson</meta:name>
                <meta:institution>UCL</meta:institution>    
                <meta:email>p.gleeson - at - ucl.ac.uk</meta:email>
            </meta:modelTranslator>
        </meta:authorList>
        
        <meta:publication>
           <meta:fullTitle>Maex, R and De Schutter, E.
           Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the
           cerebellar Granule Cell Layer. J Neurophysiol, Nov 1998; 80: 2521 - 2537</meta:fullTitle>
           <meta:pubmedRef>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9819260&amp;dopt=Abstract</meta:pubmedRef>
        </meta:publication>

        <meta:neuronDBref>
            <meta:modelName>K+ channels</meta:modelName>
            <meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table3</meta:uri>
        </meta:neuronDBref>

        <current_voltage_relation cond_law="ohmic" ion="k" default_gmax="0.179811" default_erev="-0.09">
            
            <conc_dependence name="Calcium" ion="ca" charge="2" variable_name="ca_conc" min_conc="7.55e-7" max_conc="0.050"/>
            
            <q10_settings q10_factor="3" experimental_temp="17.350264793"/>
            <offset value="0.010"/>
            
            <gate name="m" instances="1">
                <closed_state id="m0"/>
                <open_state id="m"/>
                    
                <transition name="alpha" from="m0" to="m" expr_form="generic" expr="2500/(1 + ( (1.5e-3 *(exp (-85*v))) / ca_conc))" />
                <transition name="beta" from="m" to="m0" expr_form="generic" expr="1500/(1 + (ca_conc / (1.5e-4 * (exp (-77*v)))))" />
                    
            </gate>
        </current_voltage_relation>        
      
        
        
    </channel_type>
</channelml>